Hip & Knee Research
Hip & Knee Research
Hip & Knee Research
Hip & Knee Research
Research Projects
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South Campus Research Unit for Bone and Soft Tissue
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Hip & Knee Research
ongoing studies
OR30™ Dual Mobility System
The University of Calgary Conjoint Health Research Ethics Board has approved this research study (REB20-1411)
Study Overview
Prospective, Multi-center Study to Evaluate the Safety and Effectiveness of the OR3OTM Dual Mobility System in Primary and Revision Total Hip Arthroplasty (THA) Procedures.
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Total hip arthroplasty (THA) or total hip replacement is an extremely successful intervention that significantly reduces pain, increases mobility, and restores function in patients with degenerative joint disease.
The purpose of this study is to assess the safety and effectiveness of a novel hip replacement device, the OR3OTM Dual Mobility System. The dual mobility system refers to two points of movement in the device, allowing for greater range of motion and increased resistance to dislocation.
The SCRUBS research team and the South Health Campus are just one site involved in this global study in collaboration with Smith & Nephew Inc. We aim to assess the survivability of the OR3OTM Dual Mobility Device in patients with primary and revision THA for a period of ten years.
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Current status
Recruitment Closed. Data analysis in progress.
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Sponsor
Smith & Nephew
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Lead Principal Investigator
Bilateral TKA - RCT
The University of Calgary Conjoint Health Research Ethics Board has approved this research study (REB18-0968)
Study Overview
Multi-Center Randomized Controlled Trial of Staged versus Simultaneous Bilateral Knee Arthroplasty
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Knee arthroplasty (KA) is a highly successful surgical procedure that reduces pain and restores function to over 60,000 Canadians each year. Bilateral symptomatic knee osteoarthritis (OA) is common and bilateral KA is a routine treatment for this group of patients. Bilateral KA can be performed in simultaneously (both knees replaced in a single surgery) or staged (two separate procedures, two different hospital admissions). However, it is currently unknown whether staged or simultaneous procedures are associated with better patient outcomes. The purpose of this study is to help answer the question: “Should you have both knees replaced at the same time and get it over with, or should you just do one knee replacement and see how it goes?”
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Current status
Recruitment Complete. Analysis in progress.
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Sponsor
Canadian Arthritis Society
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Lead Principal Investigator
Dr. Kelly Johnston
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Local Co-Investigator
KOAPAIN
The University of Calgary Conjoint Health Research Ethics Board has approved this research study (REB20-0019)
Study Overview
Investigation of Chronic Pain in Knee Osteoarthritis Using Brain and Joint Imaging
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The purpose of this research study is to better understand pain in knee osteoarthritis. Even though the pain in knee osteoarthritis likely begins in the joint, alterations in pain processing in the brain likely contributes to the pain experienced and affects outcomes after total knee replacement. We use magnetic resonance imaging (MRI) to take pictures of patients' knee and brain to look at the combined effects of knee damage and brain signals on pain. We also use weight-bearing computed tomography (WBCT) to assess joint changes such as bone loss and soft tissue damage. We are conducted this research on three groups of people, those prior to having total knee arthroplasty (TKA), those who have received a total TKA, and healthy controls with no previous or current injury or condition to the knee joints.
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Current status
Recruitment Open
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Sponsor
McCaig Institute for Bone and Joint Health, University of Calgary
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Lead Principal Investigator
Dr. Ashley Harris
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Knee BML Imaging Study
The University of Calgary Conjoint Health Research Ethics Board has approved this research study (REB19-0373)
Study Overview
Knee Bone Marrow Lesions Imaging: Imaging Inflammation in the Human Knee Following Acute Injury
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This research study looks at ACL injuries to assess how they heal over time and how the knee changes in the early stages of healing. ACL tears often present with bone injuries called bone marrow lesions (bone bruises). However, these bone bruises are difficult to visualize using medical imaging and therefore, it is not clear how long these bruises last after injury or how they affect recovery.
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We are interested in using advanced imaging to monitor bone bruises after an ACL injury. You may be eligible for this study if a doctor or physiotherapist suspects that you have a torn ACL, and the injury happened within the past 12 weeks. If you decide that you’d like to participate, we would assess the injury using medical imaging in the forms of MRI and CT scans at 2 time points. So you would come to the Bone Imaging Lab located at the Foothills Hospital for those scans, and each appointment would take approximately 1.5 hours.
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Current status
Recruitment Open
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Lead Principal Investigator
Dr. Steven Boyd, PhD
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Local Principal Investigator
completed studies
HIP ATTACK Trial
The University of Calgary Conjoint Health Research Ethics Board has approved this research study (REB16-0400)
Study Overview
HIP Fracture Accelerated Surgical TreaTment And Care TracK (HIP ATTACK)
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HIP ATTACK is an international randomized controlled trial of 3000 patients with a hip fracture that requires a surgical intervention. 69 sites across 17 countries recruited participants for this study. This trial investigated the effect of accelerated medical clearance and accelerated surgery compared to standard care on the 90-day risk of mortality and major perioperative complication (i.e., a composite of mortality, nonfatal myocardial infarction, nonfatal pulmonary embolism, nonfatal pneumonia, nonfatal sepsis, nonfatal stroke, and nonfatal life-threatening and major bleeding).
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Current Status
Recruitment closed. 3001 enrolled participants globally. Currently in final stages of follow up. Published in CMAJ, The Lancet and BMJ Open.
To learn more visit:
https://clinicaltrials.gov/ct2/show/study/NCT02027896
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Lead Principal Investigators
Dr. PJ Devereaux & Dr. Mohit Bhandari
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Lead SHC Site Investigator
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PRACTICE: Management of patients with hip fractures receiving anticoagulation
The University of Calgary Conjoint Health Research Ethics Board has approved this research study (REB17-1785)
Study Overview
Questionnaire of Preoperative Preferences for Anticoagulant Therapy Management in Canadian Orthopaedic Surgeons (PRACTICE)
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Direct oral anticoagulants (DOACs) are rapidly replacing warfarin for therapeutic anticoagulation; however, many DOACs are irreversible and may complicate bleeding in emergent situations such as hip fractures. With a lack of clear guidelines for the timing of surgery, the purpose of the study was to evaluate the current practices of Canadian orthopaedic surgeons who manage patients with hip fractures receiving anticoagulation via a nation-wide survey. 280 responses were submitted and the results suggest that there is a wide variability in Canada regarding the management of these patients.
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Current Status
Recruitment closed. 280 Responses. Publish in CSJ. To learn more visit: Management of patients with hip fracture receiving anticoagulation: What are we doing in Canada? | CJS (canjsurg.ca)
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Lead Principal Investigators
Dr. Neil White
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HEALTH: Total Hip Arthroplasty vs Hemi-Arthroplasty
The University of Calgary Conjoint Health Research Ethics Board has approved this research study (REB15-0955)
Study Overview
Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults with Displaced Hip Fractures (HEALTH)
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Each year, hip fracture, an injury that can impair independence and quality of life, occurs in about 280,000 Americans and 36,000 Canadians. By the year 2040, the annual healthcare costs associated with hip fractures are expected to reach $9.8 billion in the United States and $650 million in Canada. It is important to have in place optimal practice guidelines for the surgical handling of this injury. One type of hip fracture, called a displaced femoral neck fracture, is often treated with a hip replacement surgery. Patients undergoing a hip replacement may receive either a total hip replacement, in which the head of the femur and the hip joint socket are replaced, or a partial hip replacement, in which only the head of the femur is replaced. This study will compare the two different hip replacement procedures to determine which one results in better outcomes after surgery in adults aged 50 and older.
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Current Status
Recruitment closed. 1501 enrolled participants in Canada and USA. To learn more visit: Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures - Study Results - ClinicalTrials.gov
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Lead Principal Investigators
Dr. Seper Ekhtiari, Dr. Mohit Bhandari & Dr. P.J. Devereaux
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LOCAL Principal Investigators
Dr. Richard Buckley
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LOCAL SHC COLLABORATORS
Dr. Neil White, Dr. Eldridge Batuyong, Dr. Stephen Hunt, Dr. Justin LeBlanc & Dr. Marcia Clark​
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